The Center for Rehabilitation Engineering, Science & Technology (CREST)

Center for Rehabilitation Engineering, Science & Technology (CREST)

Center for Rehabilitation Engineering, Science & Technology (CREST)

A Synergistic Approach

The Center for Rehabilitation Engineering, Science and Technology (CREST) educates, mentors and trains students to integrate and apply a combined scientific, analytical, technological and business approach to emerging biomedical engineering and biomedical science areas.

CREST is one of the five distinct yet related priority research and programmatic expansions funded by a $30 million grant — one of the largest gifts in the history of Clarkson University — from the Wallace H. Coulter Foundation.

We specialize in:

  • A balanced academic exposure to the medical, social and psychological aspects of disability and its remediation.
  • Current knowledge about the pathophysiology of disability and new research tools.
  • Analytical processes to model the impairment and its functional limitations.
  • The design and development of acceptable augmentation or replacement devices, strategies or concepts.
  • Real-world design, provisioning, marketing of and training in the use, psychology and sociology of such devices.

Contact Us

The Center for Rehabilitation Engineering, Science & Technology (CREST)

125 CAMP Building
Box 5720

Phone: 315-268-6528

Email: crest@clarkson.edu

I'm grateful for many things during my time at Clarkson, but the CREST lab is undoubtedly at the top of that list. I had taken many research and undergrad lab courses; however, the CREST lab allowed me to apply my engineering knowledge to investigate and solve complex biomedical problems. CREST connected the dots between many of my previous classes and taught me how to implement the short- and long-term goals needed to complete high-level research studies.

Austin Marshall '20 BS in Biochemistry, PhD candidate in Bioscience and Biotechnology

Research Focus

CREST's focus is spread across the Coulter School of Engineering and Applied Sciences and the Lewis School of Health and Life Sciences.

Stone working on research

Current Areas of Research

Areas of research include:

  • Neural engineering
  • Biomolecular engineering
  • Biosensors
  • Biosignal processing
  • Computational biology
  • Biomaterials
  • Bioinformatics
  • Biometrics
  • Bio-entrepreneurship
  • Tissue Engineering and Regenerative Medicine
Student with a printed prosthetic

Rehabilitation Engineering

Rehabilitation engineering spans the entire engineering and research spectrum:

  • From basic science to mathematical models and sophisticated simulations/analyses.
  • From device design to clinical trials.
  • From mechanical, electrical, industrial and materials engineering to industrial design.
  • From measurement theory to human factors and quality control.
  • From clinical practice to the socioeconomic worth of technology.
Student working in the biomolecular lab

Biomedical Engineering, Biomedical Science and Bio-Entrepreneurship

Our biomedical engineering/biomedical science focus leads to a unique and synergistic approach, especially when entrepreneurship is added as a key ingredient.

  • We focus on current science, engineering, technology and the marketplace.
  • Students at Clarkson receive sought-after cross-disciplinary training.
  • CREST is a university-wide endeavor, crossing the purview of all the major schools and centers.
  • Bio-entrepreneurship partners engineering senior design capstone courses with the Reh School of Business.

My most defining experience at Clarkson has been my engagement in the labs. I was given the opportunity to both participate in and lead research that furthered my understanding of my chosen topics. I was able to get hands-on project design exposure to real-world problems in both my graduate and undergraduate careers. Not only did this educate me, it also allowed me to directly contribute to my field of interest.

Camilla Ketola '21, BS in Biology, BS in Computer Engineering MS Candidate in Electrical Engineering

Center for Air and Aquatic Resources Engineering & Sciences (CAARES)

Center for Air and Aquatic Resources Engineering and Sciences (CAARES)

Center for Air and Aquatic Resources Engineering and Sciences (CAARES)

Addressing Complex Environmental Challenges

The Center for Air and Aquatic Resources Engineering and Sciences (CAARES) aims to provide a better and more complete scientific basis for air and water quality management. We strive to understand the sources, transport and chemistry that give rise to exposure to pollutants, their potential health and welfare effects and ways in which these effects can be reduced or eliminated.

CAARES brings together world-class expertise, focusing on air and water sensing, sampling, physical and chemical analysis, fate and transport modeling and the application of computational fluid dynamics to air and water pollution problems.

In addition, we are developing new monitoring, modeling, measurement and flow management tools that can provide critical information to state and federal regulatory authorities that will help to improve environmental quality.

Recent Research

Air Pollution

The presence of contaminants in the atmosphere can produce a wide variety of adverse effects, including:

  • Increased mortality and morbidity in the public.
  • Deterioration of buildings and monuments.
  • Acidification of lakes and rivers.
  • Forest and crop damage.

The adverse health effects of atmospheric contaminants cannot be avoided by staying inside, since ambient air is transported indoors along with its pollutants, and indoor sources can add to the problem. Although we have substantially improved ambient air quality over the past 30 years, a number of problems attributed to air pollution remain. Recent studies have found strong correlations between changes in particle concentrations and increased mortality. Additionally, there has been a sharp rise in childhood asthma.

Great Lakes Fish Monitoring and Surveillance Program

This program, a revision of a program started in the 1970s, monitors fish contaminants in the Great Lakes. We have simplified the sampling, and additional emphasis has been placed on identifying emerging contaminants that may pose a risk to the Great Lakes.

Clarkson has operated this program since 2005. We have modernized legacy pollutant measurements by developing efficient sample processing and analysis procedures. Improvements include:

  • Lowering detection limits.
  • Adding additional chemicals to the analyte list.
  • Scanning for and identifying emerging contaminants.
  • Including the routine analyses of fish eggs.

We have enhanced the program by developing working relationships with laboratories from other federal agencies, states and countries.

Contact Us

Co-Directors: 
Thomas M. Holsen & Suresh Dhaniyala
CAMP Building
Box 5708

Phone: 315-268-3851

About CAARES

Learn more about our research center's efforts and collaborations:

Partners

CAARES interacts with the Syracuse Center of Excellence in Environmental and Energy Systems and other institutions, such as Cornell University, the University of Rochester, SUNY ESF and SUNY Albany. While each institution has its own research mission, there are important intersections we can use to build an integrated, state-wide research center focused on air quality issues.

By enhancing already-existing capabilities and forging active collaborative alliances, we provide critical new information on air resources and innovative new approaches for managing indoor and outdoor air quality within a competitive economic environment.

CAARES Equipment and Facilities

CAARES has analytical facilities that house a number of major instruments, as well as laboratory space specifically designed to support research. The major types of instruments are liquid chromatography-mass spectrometry (LC-MS) systems, including a triple quad for targeted analyses and QToF for full scan non-targeted analyses, and a multiple gas chromatography-mass spectrometry (GC-MS) system, including a 4-D gas chromatograph/high-resolution mass spectrometer and an inductively coupled plasma-mass spectrometry (ICP-MS) system.

CAARES also houses a wide range of instrumentation and facilities for aerosol research, including particle spectrometers (TSI APS, TSI SMPS, TSI FMPS, DMT UHSAS and DMT FM-100), aerosol generators (nebulizers, electrospray and a dust feeder), low-cost mesh networked sensors (PM and gas) and an aerosol wind tunnel.

Capabilities

A Thermo Electron ICP-MS XSeries II system is available. Innovative Infinity ion lens optics, based on a hexapole design with chicane ion deflectors, provide the lowest background specification of any quadrupole ICP-MS. This system has been used extensively to analyze air filters, soils and sediments and biological samples.

Mass concentrations are measured by gravimetry using a Sartorius MC5 microbalance in our temperature- and humidity-controlled class 1000 clean room. We continuously monitor the temperature and relative humidity to ensure compliance with 40 CFR Part 50 Appendix L requirements for the 24-hour equilibration of the filter before and after exposure to ambient aerosols.

Our SciEx X500B QTOF high-resolution Quadrupole Time-of-Flight (QTOF) system provides full-scan data for suspect screening and non-targeted analysis.

A Thermo Vanquish LC coupled to a Thermo Altis triple quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source is used for both accredited and nonaccredited analysis of PFAS.

A state-of-the-art, HEPA-filtered aerosol wind tunnel with a cross-section of three feet by four feet and test wind speeds ranging from 0.5 to 15 m/s is available for CAARES researchers and external collaborators. The tunnel is fitted with a novel moving aerosol injection system and an aerosol sensor array that combine to ensure uniform aerosol concentrations over the entire cross-section of the tunnel.

Conventional

We have numerous conventional GC-MS systems with a variety of sample introduction inlets, including headspace analysis and preconcentration systems for SUMMA canisters and Tenax traps.

Multidimensional Gas Chromatography

Our latest addition is a LECO Pegasus 4D GCxGC-TOFMS. This state-of-the-art system combines comprehensive gas chromatography with the exact mass resolution of a Pegasus HT TOFMS. This instrument is used for analyzing complex samples, primarily for emerging contaminants.

Xevo TQ-XS with APGC

Xevo TQ-XS APGC enables detection limits at ultra-trace levels to allow compliance with regulatory limits and the ability to inject less sample matrix, reducing the effects of contamination.

Inorganic

Before samples can be analyzed, they need to be acid digested. We have acquired a CEM MARSXpress that can produce temperatures of up to 260°C and pressures of 500 psi for rapid sample digestion and that processes up to 40 samples at a time.

Organic

Our DIONEX ASE300 Accelerated Solvent Extraction system prepares organic samples for processing. This unit uses elevated temperature and pressure, permitting rapid extraction of the samples with a much smaller volume of solvent than a conventional Soxhlet extraction system.

The lab also has a Fluid Management Systems (FMS) PowerPrep SPE Automated One-Step Extraction and Concentration System and an automated gel permeation chromatography (GPC) system for handling multiple samples simultaneously.

Mercury Analyses

Our mercury analysis laboratory can analyze solids, water and biota for total mercury.

Faculty and Staff

Many faculty from different departments collaborate with CAARES. In addition, we work closely with the Institute for a Sustainable Environment, where we also have faculty appointed.

Meet Our Faculty and Staff