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Education Background
Biochemistry Ph.D. - 2002 University of Freiburg, Germany
Biochemistry M.S. - 1999 Alexandru Ioan Cuza University, Iaşi, Romania
Biochemistry B.S. - 1997 Alexandru Ioan Cuza University, Iaşi, Romania
R.N. - 1991 Vaslui County Hospital
Experience
Associate Professor, Department of Chemistry & Biochemistry Clarkson University, 2015
Assistant Professor, Department of Chemistry & Biochemistry Clarkson University , 2009
Associate Scientist, Department of Oncology Mount Sinai School of Medicine, 2008
Assistant Research Scientist Skirball Institute, New York University School of Medicine, 2006
Postdoctoral Associate, Brookdale Department of Molecular, Cell & Developmental Biology Mount Sinai School of Medicine, 2003
Ph.D. Student and Researcher, Department of Biochemistry University of Freiburg, Germany, 1998
Nurse Military Service, Tecuci, Galati, Romania, 1998-1990
Nurse Internal Medicine & Psychiatry, Murgeni Hospital, Vaslui, Romania, 1988-1992
Courses Taught
- CM460-560 - Biochemistry I
- CM470-570 - Biochemistry & Biotechnology Lab
- CM463-563 - Protein Chemistry & Proteomics
- CM422-522 - Advanced Mass Spectrometry
Research Interests
Research Interests
- Analytical biochemistry
- Protein chemistry
- Mass spectrometry
- Proteomics
Current Research
We are currently focusing on proteomics investigation of various bodily fluids (sera, saliva, breast milk) for identification of biomarker signatures which are indicative of disease and/or disorder detection, or progression. In one of our projects, we focus on biomarker discovery for early detection of autism spectrum disorder and neurodevelopmental disorders (i.e. Fragile X syndrome, Smith-Lemli-Opitz syndrome). In a different project, we focus on studying depression and post-traumatic stress disorder. We also focus on early detection of the onset of breast cancer. We also use preoteomics for identification and characterization of protein post-translational modifications and of protein-protein interactions, as well as for deciphering signal transduction pathways using a combination of mass spectrometry and proteomics. In one such project, we focus on Tumor Differentiation Factor (TDF) and Jumping Translocation Breakpoint (JTB), two proteins with ubiquitous (JTB) or specific (TDF) distribution within particular cells within the body.
Awards
AWARDS
- 2021 Million Dollar Club Member, Clarkson University
- 2016 Delta Zeta Influential Professor Award
- 2016 Theta Phi Alpha Influential Professor Award
- 2016 The Minority Association of Pre-Health Students Professor Award
- 2015 Theta Phi Alpha Influential Professor Award
- 2014 Theta Phi Alpha Influential Professor Award
- 2014 HEOP Influential Professor Award
- 2013 Theta Phi Alpha Influential Professor Award
- 2012 Theta Phi Alpha Influential Professor Award
- 2011 Delta Zeta Influential Professor Award
Publications
Book:
Advancements of Mass Spectrometry in Biomedical Research, Eds. Alisa G. Woods & Costel C. Darie, Advances in Experimental Medicine and Biology Series (ISSN: 0065-2598), Springer International Publishing Switzerland, 806, DOI: 10.1007/978-3-319-06068-2. 1st Edition
Advancements of Mass Spectrometry in Biomedical Research, Eds. Alisa G. Woods & Costel C. Darie, Advances in Experimental Medicine and Biology Series (ISSN: 0065-2598), Springer International Publishing Switzerland, 1140, DOI: 10.1007/978-3-030-15950-4. 2nd Edition
http://www.springer.com/chemistry/analytical+chemistry/book/978-3-319-06067-5
Peer Reviewed Publications
- Force-Induced Near-Infrared Chromism of Mechanophore-Linked Polymers
Qingkai Qi, Gaganjot Sekhon, Richard Chandradat, Nnamdi M. Ofodum, Tianruo Shen, Jan Scrimgeour, Monu Joy, Mario Wriedt, Madhuri Jayathirtha, Costel C. Darie, Devon A. Shipp, Xiaogang Liu*, and Xiaocun Lu* J. Am. Chem. Soc. 2021 https://doi.org/10.1021/jacs.1c05923 - Proteomics and its applications in breast cancer
Anca-Narcisa Neagu, Danielle Whitham, Emma Buonanno, Avalon Jenkins, Teodora Alexa-Stratulat, Bogdan Ionel Tamba, Costel C Darie Am J Cancer Res 2021; 11(9), 4006-4049 http://www.ajcr.us/AJCR_V11N9.html - Time-Dependent Analysis of Paenarthrobacter nicotinovorans pAO1 Nicotine-Related Proteome
Marius Mihăşan, Răzvan Ştefan Boiangiu, Doina Guzun, Cornelia Babii, Roshanak Aslebagh, Devika Channaveerappa, Emmalyn Dupree, Costel C Darie ACS Omega 2021; 6, 22, 14242–14251 DOI: 10.1021/acsomega.1c01020 - Proteomic Analysis Identifies Dysregulated Proteins in Butanol-Tolerant Gram-Positive Lactobacillus mucosae BR0713–33
Siqing Liu, Nasib Qureshi, Kenneth Bischoff, and Costel C. Darie ACS Omega. 2021, 6, 5, 4034-4043 https://doi.org/10.1021/acsomega.0c06028 - Mass Spectrometric (MS) Analysis of Proteins and Peptides
Madhuri Jayathirtha, Emmalyn J Dupree, Zaen Manzoor, Brianna Larose, Zach Sechrist, Anca-Narcisa Neagu, Brindusa Alina Petre, Costel C Darie Current Protein & Peptide Science, 2021, 22(2), 92-120 https://doi.org/10.2174/1389203721666200726223336 - Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial
Ali Boolani, Daniel T. Fuller, Sumona Mondal, Tyler Wilkinson, Costel C. Darie, Eric Gumpricht Nutrients 2020, 12(7), 1922. doi: 10.3390/nu12071922 - Preparation of a Phosphotyrosine-protein Standard for Use in Semiquantitative Western Blotting with Enhanced Chemiluminescence
Nancy Kendrick, Ginny Powers, Jon Johansen, Matt Hoelter, Andrew Koll, Sofia Carlson, Devika Channaveerappa, Costel C Darie PLoS One 2020 15(6), e0234645https://doi.org/10.1371/journal.pone.0234645 - A Critical Review of Bottom-Up Proteomics: The Good, the Bad, and the Future of this Field
Emmalyn Dupree, Madhuri Jayathirtha, Hannah Yorkey, Marius Mihasan, Brindusa Alina Petre, Costel C Darie Proteomes. 2020, 8(3), 14 https://doi.org/10.3390/proteomes8030014 - Proteomic Analysis of the Lake Trout (Salvelinus namaycush) Liver Identifies Proteins from Evolutionarily Close and -Distant Fish Relatives
Emmalyn Dupree, Bernard S Crimmins, Thomas M Holsen, Costel C Darie Proteomics. 201919(24), e1800429 https://doi.org/10.1002/pmic.201800429 - Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two‐dimensional polyacrylamide gel electrophoresis and mass spectrometry
Jaco C Lux, Devika Channaveerappa, Roshanak Aslebagh, Timothy A Heintz, Meredith McLerie, Brian K Panama, Costel C Darie J. Cell. Mol. Med. 2019, 23, 3016-3020 doi: 10.1111/jcmm.14131